The reason why rabies is afraid of water is mainly because the rabies virus invades the central nervous system and spreads to various organs, causing neuron damage and elevated excitability, which makes it easy for spasm of swallowing and respiratory muscles to occur at the slightest stimulation. After invading the body from the skin or mucous membrane, rabies virus has a strong affinity for nerve tissues; after invading the central nervous system, the virus will expand centripetally to the spinal cord and replicate in large quantities, and it will rapidly enter the brain and invade the nerve cells in the brainstem, cerebellum and other parts of the brain. The rabies virus can also spread to various organs and tissues after invading the central nervous system, such as salivary glands, taste buds of the tongue, and the olfactory nerve epithelium, where the amount of virus is high. When the vagus nerve, glossopharyngeal nerve, hypoglossal nerve is damaged, the excitability is elevated, the slightest stimulation is prone to spasm of swallowing muscles and respiratory muscles, so the patient will be afraid of water, difficulty in swallowing, dyspnea and other symptoms. Rabies patients due to hear the word water, hear the sound of water flow will also appear elevated nerve excitability, followed by muscle spasm, so there will be fear of water. Patients with rabies need to go to the hospital in time for consultation and treatment so as not to delay the condition.