Edema and itching of the lower limbs may be caused by varicose veins of the lower limbs, diabetes mellitus, kidney disease, liver disease, heart disease and other factors, and it is necessary to clarify the cause of the disease and then carry out targeted treatment. 1. Varicose veins of the lower limbs: swelling, itching, pain, skin color change and other symptoms may occur in both lower limbs, mostly aggravated in the afternoon and after exertion. The symptoms can be relieved by elevating the affected limbs, wearing compression stockings and massage to promote venous return, and surgery is needed if necessary. 2. Diabetes mellitus: symptoms such as excessive drinking, excessive eating, excessive urination, emaciation and fatigue may occur, and some patients may have symptoms such as swelling, itching and pain in the lower limbs. It is necessary to standardize the treatment under the guidance of the doctor, such as taking blood sugar-lowering drugs, injecting insulin, using nutritive nerve drugs, etc., but also a reasonable diet and appropriate exercise. 3. Kidney disease: Nephrotic syndrome, glomerulonephritis and other diseases can lead to hypoproteinemia, sodium retention caused by lower limb edema, usually starting from the face, need to actively treat the primary renal disease, reduce urinary protein. 4. Liver disease: Cirrhosis and other diseases can lead to ascites, lower limb edema and other symptoms, need to actively treat the primary disease, at the same time, can be input albumin to relieve symptoms. 5. Heart disease: right heart dysfunction, systemic failure and other diseases can lead to abnormal circulation, the sagging part of the body is prone to edema, can use diuretics, cardiac drugs and other drugs. Lower extremity edema itchy cause many reasons, it is recommended that patients seek medical attention in a timely manner, relevant examinations, in order to clarify the cause of the targeted treatment.