There is no best treatment for sweaty hands and feet, which may be caused by physiological factors such as eating spicy food and mental stress, or by hyperthyroidism and vitamin D deficiency, and can be treated by medication and general therapy. 1. Physiological factors: Eating spicy food or excessive mental stress may lead to sympathetic nerve excitation, resulting in sweaty hands and feet. Generally there is no need for special treatment, maintain a light diet and adjust the mentality, most of them can improve on their own. 2. hyperthyroidism: hyperthyroidism patients due to metabolic acceleration will lead to sweaty hands and feet, you can follow the doctor’s instructions to take methimazole, propylthiouracil and other drugs to reduce the thyroid hormone, to improve the phenomenon of sweaty hands and feet. The thyroid gland is moderately enlarged above, anti-thyroid drug allergy and other phenomena, you can also use radioactive iodine for treatment. 3. Vitamin D deficiency: Vitamin D deficiency patients due to increased nerve excitability will lead to sweaty hands and feet, you can take vitamin D3 drops, cod liver oil and other drugs to treat, vitamin D deficiency will also lead to calcium deficiency, will also lead to sweaty hands and feet, should also be supplemented with calcium gluconate oral solution, calcium lactate and other drugs to treat. There are many reasons for sweaty hands and feet, after excluding physiological factors, it is recommended to be admitted to the hospital for examination and targeted treatment according to the cause.