Cephalosporin antimicrobials may affect renal function. According to the pharmacokinetic characteristics of cephalosporin, cephalosporin is excreted by the kidneys, so it may cause some impact on renal function, but the standardized use of medication according to the doctor’s instructions is usually not much effect. When an infection occurs, it is necessary to use anti-infective drugs, commonly cephalosporins, especially for gram-positive bacteria, gram-negative bacteria caused by infections such as respiratory tract infections, infections of the urinary system, the use of cephalosporins can play an effective antibacterial effect, to alleviate the discomfort of the clinical manifestations. Commonly used are cefdinir, ceftriaxone and so on. However, if cephalosporin is used in excess, it may increase the burden on the kidneys, thus causing renal impairment. Some patients with decreased renal function may aggravate the damage of renal function because the overdose of cephalosporin may cause some toxic effects on the kidneys. Patients with decreased renal function should choose the medication reasonably under the guidance of professional doctors in normal times.