The difference between chickenpox and hand, foot and mouth disease is that the type of virus infected is different, the symptoms are different, and the number of episodes is different. 1. Different types of viruses: chickenpox is caused by varicella-zoster virus infection, and hand, foot and mouth disease is caused by enterovirus and coxsackievirus, etc. 2. Different symptoms: Chickenpox and HFMD are both common in children and start with a fever, but the lesions are in different locations: Chickenpox begins with red spots and papules, then quickly turns into fluid-filled herpes, usually common on the trunk and head, then spreads to the face and finally the limbs. Hand, foot and mouth disease begins with a scattered rash and herpes seen on the hands, feet, mouth and buttocks. Herpes in the oral cavity is mostly located on the tongue, buccal mucosa and hard palate, and ulcers often occur. 3. The number of cases is different: chickenpox is usually once after the body will have immunity, will not reappear. Hand, foot and mouth disease can be repeatedly infected. Chickenpox and hand, foot and mouth disease can also be identified from the course of the disease, prognosis, etc., if the relevant needs are recommended to consult a doctor to distinguish, follow the doctor’s instructions for proper treatment.