Every morning at three or four o’clock stomach pain may be diet and other physiological factors, may also be duodenal ulcer, chronic gastritis, cholecystitis and other pathological factors. 1. physiological factors: if the night before eating cold spicy and other stimulating food or fried and other indigestible food too much, or the existence of overeating and other behaviors, it will be on the gastric mucosa stimulation, aggravate the burden of the gastrointestinal tract, resulting in patients with three or four o’clock in the morning stomach ache. If you sleep at night with a cold abdomen, you may also have a stomachache at three or four o’clock in the morning. 2. Duodenal ulcer: the typical feature is hunger pain, in the morning at three or four o’clock, the body is in the fasting state, gastric acid secretion will stimulate the ulcer at the gastric mucosa to produce pain. 3. Chronic gastritis: the patient’s gastric mucosa has a certain degree of edema, erosion and other damage, in the morning at three or four o’clock in the hungry state, gastric acid secretion increases, stimulating the gastric mucosa to produce pain, leading to the patient’s stomach ache at three or four o’clock in the morning every day. 4. Cholecystitis: patients will have sudden right upper abdominal colic, usually at night, when the pain is severe, it can be radiated to the right shoulder, scapula, back and so on. If the patient has long-term or recurring stomach pain at three or four o’clock in the morning every day, it is recommended to consult a doctor in a timely manner to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.