Caution is needed when combining probenecid and acetaminophen; probenecid may slow the decay of acetaminophen’s blood levels, which may lead to serious adverse reactions. Probenecid is an antibiotic that is mainly used for infections caused by sensitive pathogens, such as upper respiratory tract infections, bronchitis, and acute pharyngitis. Acetaminophen is a non-steroidal anti-inflammatory drug, which can be used for antipyretic and analgesic, such as fever caused by colds and mild to moderate pains such as headache, muscle aches and menstrual cramps. Probenecid may cause an increase in blood levels by inhibiting the glucuronide binding of acetaminophen, thereby slowing its clearance. It may lead to an increased chance of adverse reactions such as nausea, vomiting, sweating, abdominal pain, and may even cause serious adverse reactions such as liver damage. Adverse reactions of probenecid are commonly seen as rash, gastrointestinal discomfort, etc. It is prohibited for those who are allergic to the drug; Acetaminophen is occasionally seen as rash or itching, urticaria, drug fever, leukopenia, etc. It is prohibited for those who have severe hepatic or renal insufficiency, and it is prohibited for those who are allergic to the product. Specific medication is recommended to follow the doctor’s advice, do not self-medication.