There is no such thing as a specific number of days to successfully quit smoking. Tobacco dependence manifests itself in both somatic dependence and psychological dependence and takes different amounts of time . Physical dependence manifests itself in the form of withdrawal symptoms such as cravings, anxiety, and restlessness after a smoker stops smoking or reduces the amount of cigarettes he or she smokes. In general, they are most intense during the first 14 days of smoking cessation and then gradually decrease until they disappear. Most withdrawal symptoms last about 1 month, and some patients may experience them for more than 1 year. Psychological dependence, also known as mental dependence, is characterized by a strong subjective craving to smoke. Smoking cessation medications, such as varenicline, can ease withdrawal symptoms and assist smokers who wish to quit to improve their success rate. However, not all smokers need smoking cessation medication to quit smoking, so it is recommended to quit smoking under the guidance of a doctor.