By taking multiple therapeutic doses of venlafaxine on time and in quantity, steady state blood levels will be reached within 3 days, and optimal efficacy generally begins to be achieved in 1 to 2 weeks. Specific efficacy varies from person to person. The antidepressant mechanism of action of venlafaxine is currently thought to be related to the enhancement of 5-HT and NE effects in the central nervous system by inhibiting the reuptake of 5-hydroxytryptamine (5-HT) and norepinephrine (NE). Venlafaxine is used to treat depression, anxiety disorders, and panic attacks. The efficacy of the drug varies depending on the use. 1. If the patient’s therapeutic goal is to relieve anxiety/panic attacks, the time to achieve optimal effect is often 4-7 days earlier than the antidepressant effect. 2. The effects of venlafaxine vary at different doses. For example, when used at a low dose (75mg per day), the main effect is to inhibit the reuptake of 5-HT, and it is only when the dose is further increased that the effect of inhibiting the reuptake of NE occurs. 3. Drug effects/side effects are influenced by the administration of other substances/drugs, e.g. the combination of alcohol and venlafaxine can lead to increased sedation; the combination with Tretinoin may result in pentazocine syndrome. In summary, it routinely takes 1-2 weeks to achieve optimal results, and the full course of treatment (2-3 years) is the key to improving clinical cure rates, preventing relapse, and improving quality of life. Adverse reactions such as nausea, dry mouth and headache are common with venlafaxine, and it is contraindicated in patients with allergies, and those who are also taking monoamine oxidase inhibitors (MAOIs).