Anxiety and depression may frequently affect the quality of life of asthma patients, for example, asthma patients often feel depressed and suffocated during attacks. These mood disorders lead to reduced quality of life, frequent emergency admissions and hospitalizations, severe asthma, high doses of cortisol hormones, poor adherence to treatment and even life-threatening conditions in asthmatics. However, the results of some relevant cohort studies are controversial. A cross-sectional study conducted by Dr. Ricciardolo et al. at the University of Turin, Italy, on the impact of anxiety and depression on quality of life in outpatients with asthma, found that poor asthma control was associated with anxiety and depression. The study was published in the recent issue of AnnAllergyAsthmaImmunol. The cross-sectional study included 263 asthma patients (109 males, mean age 39.2 years) who were evaluated on clinical examination, lung function, exhaled nitric oxide, Asthma Control Questionnaire (ACT), asthma control level, visual analogue score of symptoms, and Hospital Anxiety and Depression Scale (HADS) questionnaire. The results showed that 97 (36.9%) patients had anxiety and 29 (11%) patients had depression. Of these patients, 71 were anxious in combination with depression. Both anxiety and depression were associated with poor asthma control. Depressed patients had a higher body mass index, both anxiety and depression were associated with lower ACT scores, and anxiety and depression scores on the HADS scale were moderately associated. This real-life study suggests that anxiety and depression are common comorbidities in outpatients with asthma and are associated with poor asthma control and lower ACT scores. Therefore, in clinical practice, physicians should assess for co-morbidities of asthma and psychiatric disorders. This study suggests that clinicians should focus on the assessment of patients’ anxiety and depression status along with asthma disease.