For patients with advanced gastric cancer, clinics usually adopt comprehensive treatment, including perioperative chemotherapy, radiotherapy, targeted therapy, immunotherapy and other comprehensive and personalized treatment plans to improve the quality of patients’ survival and prolong the survival period as much as possible. For advanced gastric cancer patients, surgical treatment is less likely, because most of the cancer cells have already undergone distant metastasis, and the size of their metastatic sites and quantity determine the possibility of surgical treatment, which needs to be evaluated and selected after clear diagnosis by doctors. 1. Drug therapy: Targeted therapy and symptomatic drug therapy can be used, but targeted therapy is only applicable to people with specific genes or targets, and trastuzumab is a common drug used in targeted therapy for gastric cancer. In addition, according to the clinical symptoms, omeprazole, oxycodone hydrochloride and other drugs can be used under the guidance of doctors. 2. Radiotherapy: It is commonly used for patients with progressive and advanced gastric cancer. It is used to constrain and destroy cancer cells through radiotherapy’s radioactive high-energy beams to reduce the size of tumor as much as possible and alleviate local pain. Chemotherapy can also be used to destroy cancer cells and prevent their growth, so as to relieve clinical symptoms and improve the quality of survival of patients with advanced stage as much as possible. 3. Immunotherapy: It is a way to use the function of human immune system to fight against cancer. Clinically, immunotherapy is mostly divided into three ways: immune cell therapy, antibody drug to block abnormal immune checkpoint therapy and tumor therapeutic vaccine.