Fluticasone propionate ointment can be used in the perianal area, but it should not be used for a long time. Because fluticasone propionate ointment contains fluticasone propionate belongs to the hormone, the mucous membrane of the perianal area is more abundant, the hormone will stimulate the skin mucous membrane, the prolonged use of fluticasone propionate ointment and a series of hormonal drugs will make the perianal skin mucous membrane brittleness increase, prone to subcutaneous hemorrhage or ecchymosis, so it can not be used for a long time. Fluticasone propionate ointment is mainly applied to a variety of corticosteroid-sensitive inflammatory and pruritic skin diseases, such as common eczema, seborrheic dermatitis, insect bite dermatitis and so on. If used improperly, the local skin will produce different degrees of allergic reactions. When patients have uncomfortable reactions in the perianal area, they should seek medical treatment as soon as possible and standardize the use of medication according to the doctor’s guidance.