The main pathologies of primary hypertension include:1, neurological mechanism:excessive activation of sympathetic nervous system, causing excessive release of catecholamines, such as relaxation state, excessive release of catecholamines; 2, renal mechanism:renal causes water and sodium retention, blood volume overload; 3, hormonal mechanism:excessive activation of renin-angiotensin-aldosterone system, causing water and sodium retention; 4, vascular endothelial mechanism:vascular Decreased endothelial function and carbon monoxide release, causing excessive vasoconstriction, associated with age, smoking, obesity, diabetes, hypertension, etc.; 5, insulin resistance:50% of patients with primary hypertension have insulin resistance.