Phentolamine and norepinephrine should not be combined, but norepinephrine can be used for phentolamine-induced hypotension and can raise a patient’s blood pressure. Phentolamine is an alpha receptor antagonist with vasodilatory effects. It is used clinically for left ventricular failure and hypertension caused by pheochromocytoma tumor. Its common adverse reactions include upright hypotension, nasal congestion, nausea and vomiting. Hypotension, coronary heart disease, myocardial infarction, and those who are allergic to the product are prohibited. Norepinephrine belongs to the adrenergic receptor agonist drugs, mainly used in the treatment of acute myocardial infarction, extracorporeal circulation and other causes of hypotension. Its adverse reactions include headache, slow heart rate, decreased urine output and so on. It is contraindicated in patients with cocaine intoxication and tachycardia, and is prohibited in combination with halogen-containing anesthetics and other catecholamines. Phentolamine overdose can cause hypotension, then norepinephrine can be chosen to raise the patient’s blood pressure, so the two are not combined relationship. Please use the drug according to the doctor’s instructions, and inform the physician promptly if you experience any significant discomfort after the administration of the drug.