Serious postoperative cough of pulmonary nodule is related to airway hyperreactivity, irritation and other factors, which can be controlled by oral cough suppressant medication, unsatisfactory can be combined with bronchodilator, and pay attention to the life regulation at the same time. 1. Oral medication, although postoperative cough is a normal reaction, but also need to be combined with cough suppressant drugs for control, commonly used drugs, including pentoxyverine citrate tablets, etc., to control the symptoms at an early stage. 2. Bronchodilator, if the effect of oral cough medication is not satisfactory, and there is still a serious cough, it is considered that there is a high reaction of the airway, and it can be combined with bronchodilator such as salbutamol to control the symptoms. 3. At the same time, you need to pay attention to life care, avoid the kitchen and other heavy fumes area, timely smoking cessation, appropriate exercise. The use of drugs need to follow the doctor’s instructions.