If patients have palpitations, panic attacks and chest tightness when waking up in the morning, the following points should be considered: First, we should consider the paroxysmal hypoglycemic reaction at night. When patients have transient hypoglycemia, it will trigger symptoms such as panic attacks, chest tightness, shortness of breath, dizziness and cold sweat in the morning. Second, for other endocrine diseases, symptoms of morning panic, palpitations, chest tightness and shortness of breath may also occur in cases of hyperthyroidism, hyperparathyroidism and adrenal hyperfunction. Third, for circulatory system diseases, such as patients with coronary angina, arrhythmia, heart failure, there will also be clinical symptoms and manifestations of panic, chest tightness and shortness of breath. Fourthly, if the patient has high blood pressure, especially for the elderly with increased volatility and unstable blood pressure, it will easily lead to clinical symptoms of panic, chest tightness and palpitations in the morning.