Spironolactone tablets eat with estrogen-like effect, female patients in the long-term use of among the, will affect menstruation, will appear irregular menstruation, but also cause breast pain, voice thickening, hair growth, sexual function decline, etc.. Spironolactone can be used clinically for the treatment of refractory hypertension, primary aldosteronism, or heart failure with decreased EF to take these drugs for a long time, in addition to some super indications, such as acne, or polycystic ovary syndrome with hirsutism, etc.. There are some indications for long-term use, such as heart failure with declining EF, where the drug can reduce heart failure episodes and improve the clinical prognosis of the patient. There are also some drugs that are taken for a short period of time, such as refractory hypertension, which may require spironolactone, and after the blood pressure is better controlled, the dosage can be gradually reduced or changed to other antihypertensive drugs, and primary aldosteronism can be used for a period of time. In case of surgery, spironolactone can also be stopped after adrenal adenoma is removed. If you can reduce or stop the dosage, try to reduce or stop, if you can not reduce or stop, do not arbitrarily reduce the drug.