Whether a person can live 20 years with liver fibrosis is related to the cause of liver fibrosis. If the primary disease is actively controlled, the patient’s survival period will be longer, possibly more than 20 years; if the primary disease is not controlled, the patient may develop into cirrhosis or even liver cancer, leading to death. Liver fibrosis is a pathological phenomenon resulting from prolonged damage to the liver, and common diseases that can lead to liver fibrosis include viral hepatitis, autoimmune liver disease, alcoholic liver, etc. After the discovery of liver fibrosis, it is important to make sure that the patient has a good understanding of the disease. After discovering liver fibrosis, it is necessary to actively carry out treatment, quit drinking, reasonable diet, active treatment of viral hepatitis, taking liver-protecting drugs such as glycyrrhizic acid preparations, silymarin, etc., so as to slow down the progress of liver disease, slow down the speed of liver fibrosis, and the life expectancy of the patient will be prolonged, and the patient will be able to live for 20 years or even longer. If liver fibrosis is found and effective treatment measures are not taken actively, the degree of liver fibrosis gradually becomes larger and the condition of the patient worsens, and the disease will develop into cirrhosis or even liver cancer in a few years or ten years, which will ultimately lead to life-threatening situation of the patient. Therefore, after discovering liver fibrosis, it is necessary to follow the doctor’s instructions actively for treatment.