xpert and tspot are two different tuberculosis testing techniques, which differ somewhat in diagnostic content, operational difficulty and sensitivity. 1. Diagnostic content: xpert is a kind of molecular biology detection technology, which can extract dna from the fresh sputum of the patient, so as to determine whether there is tuberculosis. In contrast, the tspot test mainly utilizes TB-specific antigens to check for the presence of T-lymphocytes, which are the effector of TB, in the patient’s body. However, this testing technology can only determine the problem of tuberculosis infection, and cannot directly diagnose tuberculosis disease. 2. Difficulty of operation: xpert test is more complicated to operate, requiring a certain degree of experience and technology, and the safety level of the experiment is also relatively high, otherwise it is easy to have an impact on the results of the test, which will lead to the emergence of false-positive situations. The tspot test is relatively simple to operate, and the requirements for professionalism are relatively low. 3. Sensitivity: compared with xpert, tspot is more sensitive because it is applicable to a wider range and does not require bacterial specimens. When carrying out tuberculosis examination, patients should choose the appropriate test under the guidance of doctors as far as possible, so as to better confirm the diagnosis of the disease.