Multiple metastases may occur in stage IV breast cancer, such as different metastatic sites, which may also show different symptoms. Breast cancer with brain metastasis, also stage IV, may show increased intracranial pressure, such as nausea, vomiting, dizziness and headache. There are also bone metastases, which may have bone pain and pathologic fractures. In addition, liver metastasis may have symptoms such as pain and discomfort in the right upper abdomen, poor appetite, jaundice, and ascites. For stage IV breast cancer, palliative chemotherapy as well as local radiotherapy can be considered to control the progression of the disease. If the conditions of endocrine therapy are met, that is, immunohistochemistry suggests that estrogen receptor and progesterone receptor are positive, it can also be combined with endocrine therapy. If human epidermal factor receptor 2, or HER2, is positive, there is also the opportunity to apply targeted therapy. If you can use targeted therapy, you may also be able to control the progression of the disease and prolong survival.