There is no oxyfloxacin ophthalmic ointment and erythromycin ophthalmic ointment which is better, due to the cause of the patient’s disease, the sensitivity of the drug is different, etc., the patient needs to follow the doctor’s instructions to use the drug. Ofloxacin ophthalmic ointment belongs to the quinolone antibiotics, can be used for the treatment of blepharitis, external blepharitis, dacryocystitis, conjunctivitis, internal blepharitis, keratitis and used in ophthalmology perioperative aseptic chemotherapy method. After use, patients may experience adverse reactions such as itching sensation of the eyelids, blepharitis, conjunctival congestion, eye pain, and redness of the eyelids, which are mostly relieved. It should be used with caution in pregnant and lactating women, and is contraindicated in patients with a prior history of hypersensitivity to this product and to quinolone antimicrobial agents. Erythromycin ophthalmic ointment belongs to macrolide antibiotics, can be used for trachoma, conjunctivitis, blepharitis and external ocular infections, after the use of eye pain, vision changes, allergic reactions and other adverse reactions should be discontinued and treated promptly. It should be used with caution in pregnant and lactating women, and is contraindicated in patients who are allergic to the product. Patients are advised to use the drug as prescribed by the doctor, do not use ofloxacin ophthalmic ointment or erythromycin ophthalmic ointment without authorization to avoid causing adverse reactions.