Gastric mucosa even if damaged, Helicobacter pylori can cause damage. H. pylori enters the stomach through the mouth, partly killed by gastric acid, partly active in the mucus layer and the surface of the epithelial cells of the mucosa of the gastric sinus, and generally not in the gastric glands and lamina propria, which avoids the sterilization by the gastric acid and is not easy to be cleared by the immune function. Even if the gastric mucosa is damaged, H. pylori can cause damage to the damaged gastric mucosa. A common treatment for H. pylori infection is quadruple therapy, which includes a proton pump inhibitor, a bismuth agent, and two antibiotics. Commonly used proton pump inhibitors include omeprazole and lansoprazole; bismuth agents include bismuth potassium citrate and bismuth pectin; and commonly used antibiotics include amoxicillin and clindamycin. If Helicobacter pylori is positive, it is recommended to follow the doctor’s advice to actively carry out treatment to reduce the occurrence of gastritis and ulcer disease.