The normal value of total bilirubin is 1.71~17.1μmol/l, cirrhosis bilirubin 250μmol/l has exceeded the upper limit of the normal value by 10 times, which belongs to a more serious situation. Cirrhosis can be divided into compensated cirrhosis and decompensated cirrhosis, compensated cirrhosis refers to the liver cells are less damaged, the liver has not been seriously damaged, liver function can be maintained normal, this time the bilirubin will not usually rise, or slightly elevated. When the bilirubin reaches 250μmol/l, which is more than 10 times of the upper limit of normal value, it belongs to severe elevation, which indicates that the hepatocyte is damaged seriously, and metabolic dysfunction occurs, if the patient is accompanied by ascites, portal hypertension and other manifestations, it means that the cirrhosis has already entered into the uncompensated stage, which is more serious, and timely treatment is needed. If bilirubin 250μmol/l is found in the examination of cirrhosis patients, it is recommended to consult a doctor in time and accept treatment actively so as not to delay the condition.