Blistering of the cornea may be caused by various microbial infections such as bacterial, fungal and viral infections such as keratitis, conical cornea or herpetic keratitis. 1. After bacterial, fungal and viral infections of the cornea, the structure and function of various layers of the cornea may be damaged, resulting in corneal clouding, formation of ulcer foci and blistering of the cornea, etc. It is necessary to consult a doctor in time to complete the auxiliary examination of the slit-lamp microscope, and then under the guidance of the doctor to give levofloxacin, ganciclovir and other anti-infective treatments. 2. Conical cornea is a limited cone-like elevation of the cornea, which may appear as a bubble on the cornea and may have highly progressive astigmatism, requiring corrective treatments such as contact lenses or corneal transplantation. 3. The number of corneal endothelial cells is so low due to various reasons, such as trauma from inner eye surgery, that there is a loss of compensation of corneal endothelial cells, and their functions such as dehydration of the cornea are destroyed, thus herpetic keratitis may occur, and corneal transplantation is needed to treat the seriousness of the condition. It is recommended that if there is obvious corneal clouding and blistering, or if there is a significant impact on vision, it is necessary to consult a doctor in a timely manner, and to improve the slit-lamp microscope and other auxiliary examinations to provide targeted treatment.