Whether Lipoic Acid with Methylcobalamin works well or not needs to depend on what disease it is used to treat, both are more effective in the treatment of diabetic peripheral neuropathy, but the efficacy of the treatment varies from person to person, and should be reasonably used under the guidance of a doctor. Lipoic acid is commonly used in the form of injections, capsules, tablets and so on. Lipoic acid is generally used for the treatment of diabetic polypoidal peripheral neuropathy. Adverse reactions of Lipoic Acid mainly include headache, nausea, vomiting, abnormal vision, urticaria and so on. It is contraindicated in people who are allergic to the product. The commonly used dosage forms of methylcobalamin are tablets, injections and capsules. It can promote nerve axonal transportation and axonal regeneration, and inhibit drug-induced neurodegeneration. It is used in the treatment of peripheral neuropathy. Adverse reactions mainly include loss of appetite, vomiting, nausea, rash, diarrhea and so on. It is contraindicated for those who are allergic to the drug. The clinical effect of the combined use of lipoic acid and methylcobalamin is affected by the severity of the disease, sensitivity to the drug and other factors, and there are individual differences. Medical advice should be followed to standardize the use of drugs.