Chronic pyelonephritis usually cannot be completely cured, patients will have repeated acute episodes, kidney function will gradually decline, and some patients may eventually lead to uremia. Chronic pyelonephritis is often caused by acute pyelonephritis, patients will have repeated acute episodes, with renal interstitial damage, serious cases will have glomerular damage, at this time, often can not be completely cured, and renal function will gradually decline, some patients may eventually lead to uremia. The treatment of chronic pyelonephritis is to prevent acute attacks as much as possible, once an acute attack occurs, it is necessary to follow the doctor’s instructions to apply antibiotic treatment, usually within two weeks, the acute attack can be relieved, but it can not be completely cured. Patients with chronic pyelonephritis with decreased renal function need to be treated with integrated nephropathy, such as renal hypertension which needs to be treated with antihypertensive drugs such as nifedipine extended-release tablets and irbesartan, and renal anemia which needs to be treated with erythropoietin or roxarestat. If it has progressed to uremia, renal replacement therapy such as hemodialysis and peritoneal dialysis is needed. All of the above drugs need to be used in accordance with medical advice. It is recommended that patients with chronic pyelonephritis go to regular hospitals in time and choose the appropriate treatment plan under the guidance of the doctor to avoid delaying the condition.