Bowenoid papulosis can be treated with recombinant human interferon a-2b gel, but it is recommended that it be treated primarily with physical therapy such as electrocoagulation or laser. Bowen-like papulosis is a sexually transmitted disease caused by human papillomavirus type 16, which is generally considered benign but has the potential to progress to invasive squamous cell carcinoma. Recombinant human interferon enhances natural killer lymphocyte activity, exerts antitumor, immunomodulatory, and viral suppression effects, and can inhibit the progression of Bowen-like papulosis. Adverse reactions include local itching, pain, burning sensation, allergy is prohibited, pregnant women, autoimmune disease, AIDS, severe heart disease patients with caution. Recombinant human interferon gel is difficult to eradicate the disease, so the main use of physical therapy is generally. Commonly used carbon dioxide laser, electrocoagulation, surgical excision, etc. to completely remove the lesions of the skin tissue, to avoid the spread or cancer. It is recommended to visit a dermatologist and follow the doctor’s instructions for treatment.