There is no best and safest way to fill the tear trough, the specific filler is related to the patient’s condition, you can choose autologous fat filler or hyaluronic acid filler, collagen filler, each has its own advantages and disadvantages. 1. Autologous fat filling: Generally, after autologous fat filling, the fat will be absorbed to a certain extent after the operation, and the filling effect may not be obvious. However, once the transplanted fat cells become active, the effect can be maintained for a long time, and autologous fat transplantation will not cause rejection. 2. Hyaluronic acid filling: Hyaluronic acid can be gradually metabolized and degraded in the human body, so the effect of hyaluronic acid filling tear trough is not permanent, usually can be maintained for about 6 to 12 months, but due to the presence of hyaluronic acid is a kind of acidic mucopolysaccharides that the human body originally has, generally will not have a rejection reaction. 3. Collagen filler: collagen can be absorbed by the body, so the effect of collagen filler tear trough usually only lasts 6 to 18 months, and collagen filler may produce a reaction. However, because it does not need to be extracted from the patient’s body, it is less painful for the patient. It is recommended that patients in need of tear trough filler visit a regular hospital to assess their condition and follow the doctor’s instructions to choose the appropriate treatment.