p-lcr is the abbreviation of large platelet ratio, low p-lcr may be caused by aplastic anemia, acute leukemia and hepatitis. 1. Aplastic anemia: the causes of aplastic anemia include autoimmune abnormalities, viral infections and chemical factors, etc. Typical symptoms include pallor, dizziness, chest tightness, shortness of breath and fever, etc., and it also leads to a gradual decrease in bone marrow hematopoietic tissue causing low p-lcr. 2. Acute leukemia: acute leukemia is a malignant clonal disease of hematopoietic stem cells, the cause of which is still unclear, and is related to biological factors, chemical factors, and certain blood diseases, which will cause dizziness, weakness, and pallor of the skin, and will also cause severe bleeding and low p-lcr. 3. Hepatitis: Hepatitis is caused by viral and bacterial infections, which can lead to loss of appetite, itchy skin, hyperpigmentation, and so on, and in serious cases, it can lead to gastric mucous membrane erosion and bleeding leading to low p-lcr. Low p-lcr may also be caused by idiopathic thrombocytopenic purpura, thrombocytopenia and other diseases, it is recommended to go to the hospital in a timely manner to determine the cause of the disease and follow the doctor’s instructions for treatment.