Isotretinoin is a common dermatologic drug used primarily for acne and other skin disorders, and is not generally used in the treatment of folliculitis. Folliculitis is caused by bacterial infection, which can be treated by oral and topical antibiotics, and surgery is considered when necessary. Isotretinoin, commonly used clinical dosage forms including gel, gel pills, soft capsules, in which the main ingredient is isotretinoin, can be used for the treatment of moderate to severe refractory cystic acne. Folliculitis is caused by a bacterial infection and is mainly characterized by itchy or painful red papules and pustules confined to the mouth of the hair follicle, sometimes spreading outwards. If symptoms are mild, treatment is usually not required. If the symptoms are obvious, topical fusidic acid cream, mupirocin ointment, ichthyolite ointment, together with oral cephalosporin, amoxicillin, etc., have the effect of killing and inhibiting the bacteria and reducing the infection. If it develops into carbuncle or boil, drain out the pus inside through surgical incision if necessary. If the inflammation is recurring and does not go away, if necessary, with infrared rays, ultraviolet rays and other forms of physical therapy, which can promote healing. Folliculitis on the skin, it is recommended not to blindly use drugs to avoid local irritation or aggravate the patient’s condition. It is recommended to go to the dermatology department of the hospital, under the guidance of the doctor to give the appropriate drug treatment.