After intravenous thrombolysis for cerebral infarction, it is important to closely observe changes in condition. If there are conditions in the hospital, it is recommended to observe the condition changes in the neurocritical ICU or in the stroke unit. The key points of observation are as follows: 1) the patient’s state of mind and pupil changes; 2) the patient’s vital signs, such as blood pressure, pulse, and respiration. Vital sign changes should be detected every 15 minutes to see if there are any significant fluctuations in blood pressure. If the blood pressure suddenly rises and the patient suddenly becomes agitated, it suggests that there is a change in the patient’s condition, and it is possible that intracranial hemorrhage occurs again during the process of intravenous thrombolysis. In this case, immediately stop the intravenous thrombolytic drugs to do cranial CT to clarify whether there is bleeding in the brain. If the CT is clear that there is no cranial hemorrhage, the thrombolytic therapy can be continued. If there is cranial hemorrhage, antagonistic drugs should be used and intravenous thrombolysis should be stopped.