The preferred treatment after diagnosis of epilepsy is medication. Medication for epilepsy is complex, and rational, standardized, well-timed and correct use of antiepileptic drugs can lead to complete seizure control. On the contrary, it may cause more harm, about epilepsy should comply with several principles of medication. First, the beginning of monotherapy Monotherapy is an important principle in the use of antiepileptic drugs, which is to choose one drug. Monotherapy should start from a small dose, slowly increase the amount to the maximum degree, observe the effect of seizure control and how the body’s adverse reactions, and then according to the effect to decide whether it is necessary to adjust the medication, the choice of monotherapy needs to be based on the prompting of electroencephalography, nuclear magnetic examination, and other results, combined with the patient’s specific condition to choose. The opposite of single-drug treatment is the combination of drugs, that is, through two or more drug treatment programs, the choice of the second drug needs to be different from the first drug’s mechanism of action, or the first drug has a synergistic mechanism of action, rather than the opposite mechanism of action, and also combined with the patient’s own condition to determine. Under what circumstances can be considered a combination of drugs 1, refractory epilepsy patients try a variety of single-drug treatment program is ineffective. 2,, Patients with multiple seizure types. Thirdly, patients with petit mal variant epileptic encephalopathy can be combined with drugs when the trial of single-drug treatment is ineffective one by one. It is best to use drugs with different principles, metabolic pathways and adverse effects. It is not advisable to combine drugs with the same chemical structure, because the combination of two or more antiepileptic drugs can reduce the efficacy of the drug. Finally, anti-epilepsy treatment is a long process, the patient must cooperate with the doctor, perseverance. Correctly grasp the timing and method of stopping the drug. Through regular and systematic treatment, some epilepsy patients can completely stop taking their medication. Whether or not the drug can be stopped, when to stop the drug is mainly based on the type and cause of epilepsy, seizures have been controlled for a period of time, difficulty and try to stop the drug response. Second, individualized treatment The medication for epilepsy is related to the type of seizure, the patient’s age, gender and other issues, which need to be considered comprehensively to use the medication, which should be done under the guidance of the doctor. For example, whether the patient has the idea of preparing for pregnancy, the degree of body obesity, age and so on. For example, if the patient is a girl who is in puberty and around the time of puberty, we should try to avoid the use of sodium valproate. Third, in accordance with the requirements of strict drug withdrawal, drug reduction The ability to stop the drug, when to stop the drug is mainly based on the type and cause of epilepsy, seizures have been controlled by the time, difficulty and try to stop the reaction of the drug and so on comprehensive consideration. Patients with idiopathic tonic-clonic seizures, typical absence seizures, or seizures that are controlled more quickly have a greater chance of stopping medication completely. Patients with symptomatic epilepsy and complex partial seizures, obligatory seizures, atypical apoplectic seizures, or a combination of multiple forms of seizures usually require long-term treatment. It is very dangerous for some patients to stop or reduce their medication without authorization because they have not had seizures for a period of time or their seizures have decreased. Drug reduction in epilepsy is a slow process, requiring the doctor to combine the patient’s EEG results and seizure situation to consider the gradual reduction of the drug, usually in 1-2 years to gradually reduce the dosage, and if there is a tendency to relapse after the reduction of the dosage, the original dosage should be resumed again. Do not stop the drug suddenly, otherwise it will incur seizures, or even trigger persistent epilepsy. Therefore, be sure to gradually stop and reduce the drug under the guidance of the doctor. Generally speaking it is the regular taking of two or more first-line antiepileptic drugs, the blood concentration reaches the effective range, continued for two years still can not control the seizure. We call this drug-refractory epilepsy, in which case surgical evaluation needs to be considered. Seventy percent of patients treated surgically can be cured by resection of the lesion, and a portion of patients with functional refractory epilepsy can also be controlled by palliative care.