Uremia is not a disease, but a group of syndromes in which water and metabolites are not effectively excreted and electrolyte disorders occur in all patients with chronic kidney disease. In the early stage, there are usually no symptoms, some people will experience fatigue, lumbago and leg weakness, frequent urination at night, most people experience loss of appetite, and generally do not pay attention to it. When uremia progresses to the late stage, symptoms of various systems of the body are obvious, and it is difficult to determine which is the most common symptom. Most people have edema, due to loss of appetite and gastrointestinal bleeding, anemia symptoms will occur, such as weakness, dizziness, pallor, water and sodium can not be discharged, which will lead to intractable hypertension, double lower limb weakness and cardiovascular system symptoms, such as decreased cardiac function, there will be chest tightness, shortness of breath and other symptoms. In short, there are so many symptoms that it is difficult to determine whether it is uremia from the symptoms.