BI-RADS grading is used clinically to characterize breast nodal lesions, and BI-RADS4c does not represent a confirmed diagnosis of cancer, but it is suggestive of a 61% to 94% risk of malignancy of the lesion. BI-RADS refers to the Breast Imaging Reporting and Data System, which is categorized into grades 0 to 6, of which BI-RADS grade 4 can be further categorized into 4a, 4b, and 4c. Those with 1.4a, need to be taken seriously clinically, but their risk of malignancy is relatively low and may be less than 30%, including patients with a family history of breast cancer, biopsy is recommended, and breast nodules are followed up for 3 months. Those with 2.4b, tend to be malignant, their risk of malignancy may range from 31% to 60%, and puncture biopsy or minimally invasive removal is strongly recommended. Those with 3.4c are further suspected of malignant potential, their risk of malignancy may be between 61% and 94%, and surgery is recommended. BI-RADS4c does not necessarily mean cancer, but it is a higher risk and it is recommended to go to the hospital for further examination, early diagnosis and early treatment.