Minimally invasive neurointerventional techniques have successfully treated two cases of cranio-orbital penetrating injuries. In the deep part of the orbit, nasal cavity and oral cavity of our skull, there is only a paper-thin layer of cranial bone separating the brain parenchyma, and this irregular layer of bone is the skull base. This irregular layer of bone is the skull base. Adjacent to it are the brainstem, which is the center of life, the aortic vessels that supply the skull, and the cranial nerves that govern the sensory activities of the five senses. In skull base injuries, most of them can be cured conservatively with minor bruising around the eyes, ear, nose, cerebrospinal fluid leakage, and distorted eyes and mouth. In severe cases, the hemorrhage is life-threatening, but the patient can still be saved in time. In particular, patients with cranio-cerebral injuries caused by inadvertent stabbing of foreign bodies into the skull through the eye orbit, nose and mouth are at the greatest risk. The outcome of the resuscitation depends on the judgment of the receiving physician, advanced examination equipment, the medical level of the treatment team and the spirit of multidisciplinary collaboration.