Blisters (“blisters”) with itching are commonly seen in chickenpox, herpetic pemphigoid, contact dermatitis and other diseases, which need to be treated according to the specific cause of the symptoms, and its treatment includes general treatment and medication and other methods. 1. Chickenpox: This disease is caused by varicella zoster virus infection, usually given symptomatic supportive therapy and antiviral therapy. Symptomatic supportive treatment includes cooling, fever reduction, local skin care, and antihistamine to relieve itching, etc. Antiviral treatment includes aciclovir, famciclovir, and so on. 2. Herpetic pemphigoid: this disease is an autoimmune disease, erythema, papules, blisters, blisters, etc. can appear all over the body, which can be accompanied by intense itching, usually given general treatment and drug therapy. General treatment includes nutritional support, strengthen skin care, avoid scratching to prevent infection, etc.; drug therapy is mainly glucocorticoid such as prednisone, immunosuppressant such as methotrexate. 3. Contact dermatitis: this disease is an allergic disease, often appearing in the area of contact with allergens, erythema, papules, blisters, etc., which may be accompanied by intense itching, usually given general treatment, drug treatment, etc. The former includes removing the allergens, avoiding scratching and preventing infection. The former includes removing the allergen and avoiding re-exposure; the latter includes local medication (such as glucocorticoid creams like dexamethasone) and systemic medication (such as antihistamines like loratadine). It is recommended that patients with itchy blisters go to regular hospitals for timely consultation and standardized treatment under the guidance of a doctor after a clear diagnosis, rather than blindly using medication to avoid causing serious adverse reactions.