Patient question: In September 2012, my husband’s chromosome was found to be 47XYY. In August 2012, there was a fetus of seven and a half months with no heartbeat, and the cause of fetal arrest was unknown at that time because of the lack of hospital conditions. What are the chances of having a healthy baby naturally? What are the chances of conceiving a healthy baby naturally? Is the high septum value associated with the last miscarriage also related to this problem? Doctor: The fertility of 47,XYY men is normal, and long-term follow-up of 47,XYY men shows that their offspring are not significantly more likely to have chromosomal abnormalities than normal men. Fetal abortion may be due to other causes. If you conceive again and become pregnant, amniocentesis is recommended at 16-22 weeks of gestation for fetal karyotype analysis. Patient question: Hello doctor! What you are telling me is that a male with chromosome 47.XYY has little chance of passing it on to his offspring, right? The fetal septum value was 9.5 at 28 weeks, but the doctor said it was high, is this related to chromosome 47XYY? Is it related to chromosome 47XYY? And if the fetus has no heartbeat after half a month, is it related to the high septum value? Also, does chromosome 47.XYY decrease the sperm survival rate? Doctor: 1. Long-term follow-up surveys of men with 47,XYY show that their offspring are not significantly more likely to have chromosomal abnormalities than normal men. That is, 47,XYY is not the cause of chromosomal abnormalities in fetuses, which can occur in normal fetuses. The normal septum cavity is generally considered to be no larger than 10 MM. In your case, the septum cavity is not significantly enlarged. The fetal arrest should be due to other reasons. 3. The fertility of 47,XYY males is normal, which means there is no clear relationship with reduced sperm viability.