The treatments for degenerative changes of the knee joint mainly include surgical and non-surgical treatments, and the purpose of treatment is mainly to reduce or eliminate knee pain, prevent or correct knee deformity, and improve the quality of life of patients. 1.Drug therapy:The main purpose is to reduce pain and inhibit bone resorption. Such as estrogen, selective estrogen receptor modulators. Diphosphonates, calcitonin, etc. Among them, estrogen receptor modulators are especially suitable for the treatment of postmenopausal women with degenerative osteoarthritis. 2. Surgical treatment: For patients with poor results of non-surgical treatments, surgical methods are often adopted to achieve the purpose of treatment. For example, total knee replacement, fibula osteotomy, proximal tibia osteotomy and other procedures. It is recommended that patients seek professional medical help as soon as possible, and customize individualized diagnosis and treatment plan according to their own conditions, in order to achieve the best therapeutic effect. The above drugs should be used under the guidance of a doctor, avoid self-medication.