Research in the treatment of gliomas is advancing rapidly, but most are still incurable. After treatment of both low-grade gliomas and highly malignant gliomas, the majority of patients will relapse after a long or short period of time. What is the treatment after recurrence? Whether it is radiotherapy, chemotherapy or surgery again, many patients and their families do not know how to choose, and even the wrong choice increases the patient’s suffering and shortens the patient’s survival, especially patients who have chosen Gamma Knife and high-dose radiotherapy again. In fact, if the patient and family have a strong desire to prolong life and reduce pain, and the patient is in good health, the site of recurrence and the extent of the tumor allows surgery, the best treatment for recurrent glioma is still surgery! After surgery, according to the molecular pathology results, supplemented with chemotherapy + (or) targeted therapy/gene therapy, etc., the survival and quality of life are much better than pure conservative treatment (no surgery). Of course, the risk of secondary surgery is slightly greater than the first, such as a 5% increase in the incidence of infection, and the cost of treatment is also increased, and it cannot be cured.