HPV (human papillomavirus) 31 and 53 infections, whether it is serious can not be generalized, hidden infection is not serious, causing cervical lesions may be serious. 1. not serious situation: most women infected, is a hidden infection, no symptoms, most of the checkups found, most of the year or so will be self-healing, this situation is not serious. 2. potentially serious situation: if persistent infection, may cause cervical lesions or even pre-cancerous cervical lesions, this situation is potentially serious, should be timely cervical conization. So infection with a positive HPV high-risk type should be taken fully seriously, but don’t be overly alarmed, because infection with this virus in the cervix still occurs frequently, and most of them will turn negative in about 1 year. If persistently positive, it is necessary to review cervical TCT and colposcopy regularly to see if there are any cervical intraepithelial neoplasia, precancerous lesions, and so on. HPV31 and 53 positive patients are advised to follow up treatment under the guidance of their doctors.