Toothache with leukemia is generally considered to be caused by oral diseases or local infiltration of leukemia, and it is necessary to clarify the cause of the disease and then treat the cause. 1. Dental calculus or dental caries: if the toothache of leukemia patients is caused by dental calculus or dental caries, they can go to the stomatology department to receive scaling treatment or root canal treatment, and pay attention to oral hygiene in general. 2. Periodontitis or gingivitis: when suffering from periodontitis or gingivitis, toothache may also occur, in this case, the treatment mainly includes basic treatment such as scaling and scraping, as well as medication and surgical treatment. 3. Localized infiltration of leukemia: when localized infiltration of the oral cavity occurs in leukemia, the symptoms of toothache may also appear, in this case, it is usually accompanied by spontaneous bleeding of the gums, low-grade fever, fatigue, poor mental health and other symptoms. At this time, the symptoms of toothache are usually ineffective after local treatment, and the pain and bleeding symptoms may also worsen, requiring further control of leukemia. When leukemia patients experience toothache, they should seek timely medical treatment to clarify the cause of the toothache and receive appropriate treatment.