There is no exact time when GERD will cause a disorder, but it may become cancerous if it continues to progress. Gastroesophageal reflux disease (GERD) is a condition caused by the return of stomach or duodenal contents into the esophagus. Typical symptoms are heartburn and acid reflux, and when it continues to develop it can lead to serious complications such as esophageal strictures, ulcers, bleeding and Barrett’s esophagus. Among them, Barrett’s esophagus refers to esophageal squamous epithelium being replaced by columnar epithelium of the stomach or small intestine, suggesting long-term stimulation of chronic inflammation, which is a precancerous lesion of esophageal adenocarcinoma, and often causes esophageal adenocarcinoma. Although GERD has a certain risk of becoming cancerous, not all GERD will develop into cancer. It is recommended that patients with GERD should be actively treated under the guidance of a doctor, which usually has a better prognosis and does not usually cause cancer.