Alcohol hand blisters swollen may be due to local allergic reactions, it is recommended to go to the hospital targeted use of anti-allergy drugs. Alcohol has a certain dehydrating effect, so it will not lead to hypotonic tissue edema like water. Swelling of the hands after exposure to alcohol may be due to an allergic reaction resulting in localized edema. It is recommended to remove the hands from contact with alcohol immediately and to rinse them off with water. For severe swelling, topical glucocorticosteroids such as tretinoin cream can be used to control the local inflammatory reaction. Oral antihistamines such as loratadine and fexofenadine are also an option. If necessary, dexamethasone and other drugs can be used systemically for a short period of time. If it is clear that the allergy is caused by drugs, it is recommended to avoid contact with alcohol products after recovery. Dexamethasone is recommended to be used under the supervision of a clinician.