Severe pancreatic necrosis is often indicative of severe acute pancreatitis and is usually not completely curable. Pancreatitis is a common acute abdominal disease, the condition is complex and variable, the degree of severity varies, serious cases can be complicated by systemic multi-organ failure, the morbidity and mortality rate of about 15%, even if cured, but also will be left with different degrees of pancreatic insufficiency. The treatment of severe pancreatic necrosis mainly includes searching for the cause of the disease and actively controlling the inflammatory response. Due to the rapid progression of the disease, patients need to be carefully monitored and closely observed for changes. Mainly symptomatic supportive therapy, fluid supplementation within 24 hours of disease onset is the most effective, which can control the occurrence of systemic inflammatory reaction, maintain normal respiratory function (positive pressure mechanical ventilation if necessary), maintain intestinal function (laxation, oral antibiotics, etc.), and continuous blood purification is needed when acute renal insufficiency occurs. In addition, there is the reduction of pancreatic fluid secretion by fasting and application of growth inhibitors, which relieves the symptoms to some extent. Severe pancreatic necrosis is a critical condition, and once diagnosed, the patient should actively cooperate with the physician to avoid the progression of the disease and its adverse consequences.