It is also normal for patients with tuberculosis to have a negative sputum test. For tuberculosis, some patients are positive for sputum bacteria, that is, sputum looking for antacid bacilli is positive, combined with the patient’s clinical symptoms, lung CT as well as sputum test results, can be diagnosed as tuberculosis. Some patients with tuberculosis are sputum-negative, such patients are relatively difficult to diagnose, and need to do further examination, first of all, need to do the PPD test or T-SPOT test, and further bronchoscopy, the nature of the lung lesions can be clarified after these related examinations, and then can be directly anti-tuberculosis treatment. If the nature of the lung lesion can be clarified after these examinations, then anti-tuberculosis treatment can be carried out directly. If the lung lesion is still unclear or doubtful, then lung puncture examination is needed to clarify.