The most effective treatment for patients with stage III breast cancer is preoperative neoadjuvant therapy followed by radical resection surgery. Preoperative treatment includes two cycles of systemic intravenous chemotherapy and local radiation therapy to reduce the tumor stage, local fusion, reduction of enlarged lymph nodes, and timely surgery after the reduction of primary breast cancer lesions, and after surgery, adjuvant treatment options are chosen based on detailed tumor biological behavior and pathological stage. Long-term endocrine therapy is needed for breast cancer, because breast cancer patients are also prone to lymph node metastasis and hematogenous metastasis, and later on they are also prone to metastasis to bone tissues, which manifests itself in significant length; anti-bone metastasis treatment can also be chosen according to the condition. It is also important to monitor the changes of blood routine and internal environmental indicators, and pay attention to calcium supplementation to prevent the occurrence of hypocalcemia.