Red spots under the skin of the palm of the hand may be caused by purpura, trauma, drug rash, eczema and other causes. 1. Purpura: allergic purpura, idiopathic thrombocytopenic purpura can cause subcutaneous capillary rupture, which may lead to red spots under the skin of the palm. 2. Trauma: subcutaneous capillary rupture due to localized over-exertion, over-squeezing, etc. can also lead to red spots under the skin of the palm. 3. Drug rash: allergic reactions caused by systemic medication or localized medication may also lead to red spots under the skin of the palms. 4. Eczema: Inflammatory skin reactions caused by internal and external stimuli can also lead to red spots under the skin of the palms. Red spots under the skin of the palm of the hand, there may be other causes, need to go to the hospital in a timely manner to check, clarify the cause of the disease in the doctor’s guidance under the standardized treatment.