Pancreatic tissue atrophy with interstitial fibrotic hyperplasia means that the pancreas has shrunk in size and has become fibrotic. This result is common in patients with intraductal stones and chronic pancreatitis. Pancreatic duct stones will cause high pressure in the pancreatic duct, pancreatic fluid secretion is blocked, the internal and external secretion function of the pancreas is gradually weakened, and the gland appears to be atrophic, and at the same time, the retrograde pancreatic fluid will cause persistent damage to the cells in the pancreas, and in order to repair the damage, the organism will allow more fibrous connective tissue to intervene, and interstitial fibrotic hyperplasia will occur. Patients with chronic pancreatitis are often the result of chronic, excessive alcohol consumption. Alcohol can cause direct damage to the pancreas, leading to pancreatic follicular atrophy, and gradually the whole pancreatic tissue atrophy; at the same time stimulate the pancreatic fluid secretion increases, inducing recurrent episodes of pancreatitis, the organism in order to repair the damage, the same will appear fibrous repair process, thus appearing in the mesenchymal fibrotic tissue hyperplasia. If the diagnosis of pancreatic tissue atrophy with interstitial fibroplasia is confirmed, it is recommended to carry out standardized treatment as early as possible to reduce the adverse effects of the disease.