The strong oxidizing effect of ozone can destroy the incomplete nucleus pulposus and nucleus pulposus cells, making the treatment more complete and less likely to recur; the sterilizing effect of ozone can prevent and treat infections; ozone oxidizes inflammatory mediators to achieve anti-inflammatory effect, which can relieve the patient’s pain and improve the treatment effect; ozone can reduce nerve root edema and adhesions caused by trauma by antagonizing the release of immune factors in the inflammatory response. Ozone can reduce nerve root edema and adhesions caused by trauma by antagonizing the release of immune factors in the inflammatory response. Indications (1) Nerve root pain associated with a limited disc herniation of less than or equal to 6mm. (2) Clinical history and physical examination findings consistent with radiographic findings, all less than 6 mm. (3) Duration of pain greater than 6 months. (4) Failed conservative treatment includes physical therapy, diagnostic and therapeutic injections, oral analgesics and anti-inflammatory medications. (5) X-ray fluoroscopically guided transvertebral injection of local anesthetics and short-term response (<2 weeks) to symptomatic levels of corticosteroids.