When a patient has a colonoscopy that suggests low-grade intraepithelial neoplasia, surgery is generally required. Low-grade intraepithelial neoplasia often manifests as colon polyps, which are precancerous lesions. Although its cancer rate is lower than that of high-grade intraepithelial neoplasia and intermediate-grade intraepithelial neoplasia, it is still at a higher risk of becoming cancerous compared with that of normal people. Patients with low-grade epithelial sarcoma may develop cancer if they do not undergo active treatment, so these patients need active treatment. Generally speaking, colonoscopic resection is preferred, while other treatment modalities include cryotherapy and laser therapy. For patients with low-grade epithelial sarcomatoid lesions indicated by colonoscopy, they should go to regular hospitals for consultation in time, so as not to delay the treatment of the disease. Regular review is also needed after surgery.